The barbiturates: chemical constitution and nomenclature.

نویسنده

  • J B LLOYD
چکیده

BARBITURIC acid was first synthesized by Conrad and Guthzeit in 1882, and in 1903 the 5:5-diethyl derivative was introduced into medicine as a hypnotic by Carl Fischer and von Mering, under the name of Veronal. In the past, barbituric acid was usually regarded as the cyclic ureide of malonic acid, i.e. as malonyl urea, and its structural formula written in a form which emphasized this relationship. Systematically it is more correct to regard it as a pyrimidine derivative and to write its formula as shown in figure l(a).

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عنوان ژورنال:
  • British journal of anaesthesia

دوره 29 10  شماره 

صفحات  -

تاریخ انتشار 1957